Should the grading of colorectal adenocarcinoma include microsatellite instability status?

C Rosty; EJ Williamson; M Clendenning; RJ Walters; AK Win; MA Jenkins; JL Hopper; IM Winship; MC Southey; GG Giles; DR English; DD Buchanan

Journal article

Should the grading of colorectal adenocarcinoma include microsatellite instability status?

C Rosty, EJ Williamson, M Clendenning, RJ Walters, AK Win, MA Jenkins, JL Hopper, IM Winship, MC Southey, GG Giles, DR English, DD Buchanan

Human Pathology | W B SAUNDERS CO-ELSEVIER INC | Published : 2014

DOI: 10.1016/j.humpath.2014.06.020

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Abstract

Adenocarcinomas of the colon and rectum are graded using a 2-tiered system into histologic low-grade and high-grade tumors based on the proportion of gland formation. The current grading system does not apply to subtypes of carcinomas associated with a high frequency of microsatellite instability (MSI), such as mucinous and medullary carcinomas. We investigated the combined effect of histologic grade and MSI status on survival for 738 patients with colorectal carcinoma (48% female; mean age at diagnosis 68.2 years). The proportion of high-grade adenocarcinoma was 18%. MSI was observed in 59 adenocarcinomas (9%), with higher frequency in high-grade tumors compared with low-grade tumors (20% v..

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University of Melbourne Researchers

Christophe Rosty Author

Mark Clendenning Author

Aung Ko Win Author

Mark Jenkins Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

The study was supported by grants from the National Health and Medical Research Council (NHMRC), 209057, 396414, and 509348. J.L.H. is an Australian NHMRC Senior Principal Research Fellow. M.A.J. and M.C.S. are NHMRC Senior Research Fellows. A.K.W. is an NHMRC Clinical Research Early Career Fellow.